Fresh analysis suggests that patients who stop using popular weight-loss injections like semaglutide or tirzepatide may regain lost weight far faster than those who end conventional diet and exercise plans.
Findings released in a leading medical journal points out that while obese individuals frequently drop about a fifth of their total mass while on the medication, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using such treatments need to be aware of the risk of rapid rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
This pace of regain means a return to original weight in about a year and a half.
Weighing Treatments
The study, which reviewed 37 of studies involving over 9,000 of participants, contrasted the effects of these new drugs with conventional dieting.
Scientists note that people who shed pounds through dieting typically see a more gradual creep back—perhaps 0.1 kg a month—post-intervention.
The Reason for the Quick Regain
Experts believe the mode of action of the jabs accounts for the heightened rebound.
These medications mimic a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 concentrations far above than normal might result in the body to generate a reduced amount of its endogenous GLP-1, and could diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this GLP-1 'fix' results in hunger is no longer kept in check, making excessive eating a significant risk."
A Chronic Issue?
Health authorities recommend the jabs for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Professionals argue that, given the significant potential of weight regain, the treatment might need to be life-long.
This opinion is echoed by pharmaceutical companies, who state that the results "underscore the chronic nature of obesity," akin to managing diseases like hypertension.
User Experiences
Users who have discontinued the jabs explain a sudden resurgence of cravings.
"It felt as if a trigger flipping and you're instantly ravenous," described an individual.
The struggle is exacerbated if users have not established permanent dietary or behavioural changes during therapy.
Significant Adoption
Figures show that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with desire remaining high.
- Use is greater among women than men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
Ultimately, clinicians emphasize that while these medications are effective agents for weight loss, they are not a magic solution and lasting health benefits relies on combined behavioural changes.
